Ameliorative effects of apigenin on a rat model of endometriosis

Objectives: Apigenin and parthenolide as natural products have potent antioxidant anti-inflammatory outcomes that could make them a perfect option for endometriosis therapy. This study aimed to determine the effects of apigenin on created endometrial implants in rat model endometriosis. Methods: Thirty-nine mature, female Sprague-Dawley rats were assigned randomly six experimental groups four weeks after induction. Group 1 (n = 5): Control (CTRL) opened closed abdomen; 2 6): Peritoneal ovarian (POE) + drug-free; 3 7): POE+ (APG) (50 mg/kg); 4 Parthenolide (PTL) (10 5 mg/kg) 6 DMSO. An was created, histopathological analysis biochemical evaluation performed. Serum peritoneal levels pro-and-anti-inflammatory cytokine, oxidative stress implant tissue measured. Results: IL-37 decreased significantly APG-treated group compared drug-free (p 0.016). The peritoneum ovary histopathologic scores lower 0.001) PTL-treated comparison group. index (OSI) values increased statistically group, 0.001). However, OSI 0.003). Conclusions: application caused decrease an improvement grade. may be novel therapeutic agent treatment